IDENTIFYING ASYNCHRONIES: EXPIRATORY WORK

Identifying asynchronies: Expiratory work

Mechanical ventilation is used to improve gas exchange and unload the L-Methylfolate respiratory muscles allowing for their rest and recovery, which require good synchronization between the patient and the ventilator.Spontaneous respiratory effort is generally preferred because it reduces atelectasis, improves oxygenation, and may prevent disuse di

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ROS-responsive nanoparticle-mediated delivery of CYP2J2 gene for therapeutic angiogenesis in severe hindlimb ischemia

With critical limb ischemia (CLI) being a multi-factorial disease, it is becoming evident that gene therapy with a multiple bio-functional growth factor could achieve better therapeutic outcomes.Cytochrome P450 epoxygenase-2J2 (CYP2J2) and its catalytic products epoxyeicosatrienoic acids (EETs) exhibit pleiotropic biological activities, including p

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Petrosal Ganglion: a more complex role than originally imagined.

The petrosal ganglion is a peripheral sensory ganglion, composed of pseudomonopolar sensory neurons that innervate the posterior third of the tongue and the carotid sinus and body.According to their electrical properties petrosal ganglion neurons can be ascribed to one of two categories: i) neurons with action potentials presenting an inflection (h

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Exploring the Therapeutic Potential of Traditional Antimalarial and Antidengue Plants: A Mechanistic Perspective

Malaria, Irons a highly perilous infectious disease, impacted approximately 230 million individuals globally in 2019.Mosquitoes, vectors of over 10% of worldwide diseases, pose a significant public health menace.The pressing need for novel antimalarial drugs arises due to the imminent threat faced by nearly 40% of the global population and the esca

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